CJC 1295 DAC Peptide | CAS 446262-90-4

CJC 1295 DAC Peptide Specifications

CJC 1295 DAC Key Features

• Research-Use Designation: Exclusively synthesized as a research use CJC-1295 DAC compound for life science, biochemical, and academic laboratory applications.
• Lyophilized Peptide Format: Supplied in a highly stable, freeze-dried (lyophilized) white powder form to preserve structural integrity during transit.
• DAC-Modified Peptide Structure: Formulated with CJC-1295 with DAC, incorporating a structural modification that influences its molecular bonding properties.
• Laboratory Handling Considerations: Requires precise analytical scales and standard laboratory reconstitution protocols using sterile reagents prior to evaluation.
• Strict Storage Recommendations: Guidelines for CJC-1295 DAC storage specify deep-freeze environments to prevent enzymatic degradation and hydrolysis.
• Rigorous Quality Control: Synthesized under stringent quality standards to ensure high chemical purity and analytical consistency across research trials.

CJC 1295 DAC Overview

CJC-1295 DAC is a synthetic, 30-amino-acid peptide analog that functions structurally as a modified tetrasubstituted GHRH mimetic. In the field of life science research, this compound is studied for its interactions with specific cellular receptors and its distinct biochemical profile. The foundational sequence is modified from the first 29 amino acids of endogenous GHRH, with specific substitutions engineered to enhance resistance to rapid enzymatic cleavage by dipeptidyl peptidase-4 (DPP-4).

The Role of Drug Affinity Complex (DAC)

The defining characteristic of this specific variant is the addition of the Drug Affinity Complex (DAC). DAC technology involves the conjugation of a non-reactive maleimide group via a linker to the C-terminus of the peptide chain. In experimental environments containing plasma proteins, this maleimide group is designed to form a covalent bond specifically with endogenous albumin.

By binding to albumin—a highly stable and abundant transport protein—the peptide avoids rapid renal filtration and enzymatic breakdown. This structural modification alters the compound’s pharmacokinetics, resulting in a significantly extended half-life compared to the non-conjugated peptide variant.

Laboratory Research Context

In academic and industrial research settings, CJC-1295 with DAC serves as a vital tool for exploring long-term peptide signaling dynamics. Because the compound exhibits prolonged stability in solution when exposed to specific media, researchers can analyze continuous receptor-ligand interactions without requiring frequent re-introduction of the peptide sample. This makes it an ideal candidate for comparative stability assays, structural biology research, and cellular signaling mapping.

What is CJC-1295 DAC?

From a scientific classification perspective, CJC-1295 DAC is categorized as a synthetic peptide analog belonging to the secretagogue class. Its development stems from efforts to understand how structural modifications to native peptide hormones can influence their structural resilience and binding kinetics.

The baseline peptide sequence incorporates four strategic amino acid substitutions at positions 2, 8, 15, and 27. These alterations replace the native, vulnerable residues with more stable alternatives, protecting the peptide core from immediate enzymatic degradation. The addition of the Drug Affinity Complex represents a secondary tier of engineering, creating a macromolecular complex once exposed to specific binding proteins.

In laboratory models, this complex exhibits a high degree of specificity for GHRH receptors, allowing researchers to study downstream secondary messenger cascades, such as the cyclic adenosine monophosphate (cAMP) pathway, over extended observational windows.

CJC-1295 DAC in Scientific Research

Laboratory investigations utilizing CJC-1295 DAC peptide focus primarily on its structural attributes and its interactions within isolated biological systems. Because it resists rapid breakdown, it allows for long-term experimental observations regarding how prolonged receptor activation influences intracellular signaling networks.

Peptide Signaling and Experimental Methodology

Researchers utilize this compound to explore the kinetics of continuous receptor saturation. In cell culture studies, the methodology typically involves introducing the reconstituted peptide to cellular assays to observe:

• Changes in intracellular signaling molecules.
• Receptor downregulation and internalization patterns.
• Gene expression profiles linked to pituitary secretagogue pathways.

Furthermore, comparative studies leverage this peptide to evaluate the differences in structural degradation rates between modified and unmodified GHRH analogs under various environmental conditions, such as fluctuating pH scales and temperature gradients.

CJC-1295 DAC vs. CJC-1295 No DAC

The choice between utilizing the DAC modified variant or the non-DAC variant depends entirely on the design of the laboratory protocol. Below is a structural and comparative analysis of their laboratory profiles:

Storage and Handling Guidelines

Appropriate preservation of the lyophilized CJC-1295 DAC example is vital to ensuring reproducible and exact speculative information.

Temperature and Moisture Considerations

In its freeze-dried state, the peptide ought to be kept in a committed lab fridge freezer maintained at -20 ℃ or reduced. For extended storage space expanding past numerous months, keeping the temperature at -80 ℃ is recommended. Dampness is one of the primary stimulants for peptide deterioration; for that reason, vials have to continue to be hermetically secured, and humidity levels within the storage space container should be reduced with using desiccants.

Reconstitution and Laboratory Handling

Before opening up the vial, the sample must be allowed to reach space temperature level within a laminar flow hood to stop condensation from creating inside the container upon opening. Reconstitution has to be performed utilizing a suitable bacteriostatic or clean and sterile research laboratory solvent, presented carefully down the internal glass wall surface of the vial to reduce frustration.

Vital Managing Note: Prevent vigorous shaking or vortexing of the reconstituted solution, as mechanical anxiety can interfere with the delicate tertiary and second frameworks of the peptide chain, providing the example pointless for accurate clinical evaluation.

Frequently Asked Questions

What is CJC-1295 DAC?

CJC-1295 DAC is an artificial, laboratory-engineered peptide analog of Growth Hormone-Releasing Hormonal Agent (GHRH). It includes 4 amino acid substitutions in addition to an affixed Medication Fondness Complex (DAC) to customize its metabolic security during research study applications.

What does DAC stand for?

DAC means Medicine Fondness Complicated. It is a molecular modification containing a maleimide affinity group that allows the peptide to bind covalently to albumin proteins, considerably slowing its destruction rate in test settings.

What is the difference between CJC-1295 DAC and NO DAC?

The core distinction lies in the visibility of the Medication Fondness Complex. The DAC version binds to deliver proteins, broadening its operational half-life over a number of days, whereas the No DAC variation lacks this complicated and undergoes quick enzymatic break down within minutes or hours.

How should CJC-1295 DAC be stored?

For ideal conservation, the lyophilized powder needs to be stored in a dry, dark location at temperatures listed below -20 ℃. When reconstituted right into an option, it needs to be kept cooled at 2 ℃ to 8 ℃ and made use of within a strict, short timeframe to stay clear of deterioration.

What does lyophilized peptide mean?

A lyophilized peptide is a substance that has actually gone through a specialized suspended animation process to eliminate water and moisture content. This technique maintains the chemical framework of the peptide for long-term transportation and storage space.

Is CJC-1295 DAC intended for human use?

No. This product is assigned purely as a research usage CJC-1295 DAC compound. It is developed specifically for research laboratory screening, in vitro evaluation, and life science testing. It needs to not be presented to humans or pets beyond authorized research protocols.

What solvent should be used for reconstitution?

Researchers normally make use of sterile bacteriostatic water or clean and sterile regular saline remedy for reconstitution, depending upon the details requirements of the downstream analytical assay.

Can the peptide be frozen after it has been reconstituted?

Icing up a peptide after it has been reconstituted is usually discouraged, as the formation of ice crystals can cause architectural fracturing of the peptide bonds, changing the substance’s purity and effectiveness in research study trials.

Research Notes

Notification: This item is assembled and supplied exclusively for instructional, scholastic, and research laboratory study functions. It is not a medication, clinical device, cosmetic, or foodstuff. The biochemical information provided below details documented clinical monitorings within released literary works and chemical data sources. All experimental handling has to be performed by certified research laboratory specialists using appropriate individual protective tools (PPE) based on local biosecurity and research laboratory safety and security guidelines.

Scientific References

1. Peer-Reviewed Journals: For detailed insights into GHRH analogs, refer to studies published in The Journal of Clinical Endocrinology & Metabolism or Endocrinology, focusing on structural modifications of secretagogues.
2. Research Institutions: Consult documentation from national academies of science regarding peptide synthesis and affinity complex engineering.
3. Scientific Databases: Review structural, mass spectrometry, and molecular weight data via PubChem (CID 11476145) or the UniProt database.