AOD 9604 Peptide | AOD9604 CAS: 221231-10-3

AOD 9604 Peptide Information

AOD 9604 Key Features

• Strictly Research-Use: Formulated exclusively to be used in laboratory experiments, in vitro tests, and animal models studies.
• Lyophilized peptide Format: Supplied in a freeze-dried, stable cake to maintain molecular integrity and minimise degradation.
• Premium Purity Analytical: Manufactured using rigorous high-performance liquid crystallography purification protocols.
• Storage Recommendations Verified: Optimized to ensure long-term stability under sub-zero conditions.
• Targeted Molecular Research Is ideal for researchers analyzing growth hormones fragments and structural peptides.
• Controlled laboratory handling: Requires standard, aseptic reconstitution before experimental application.

Product Overview

AOD 9404, a synthetic peptide, has attracted significant interest in the research community. It is structurally an analog to the C-terminal human growth hormone region, isolating the residues 177-191. An additional terminal tyrosine was added to stabilize the chain. This specific modification is being studied in laboratory research to better understand how larger hormones that are isolated interact with receptors on cells without activating the entire spectrum of growth hormone cascades.

Scientific Origin and Development

The development of AOD 9604 peptide is a result of structural biology efforts aimed to delineate the functional regions of a complete 191 amino acid growth hormone molecule. Scientists hypothesized that different biological actions of the hormone parent could be isolated through the synthesizing of truncated segment. Structural biochemists focused on the 177-191 segment to create a stable variant that could be evaluated in isolated biochemical environment.

Context for Laboratory Research

In modern life science research, AOD 9604 primarily is used to investigate metabolic regulation, binding affinities of lipids, and enzyme pathways at the cell level. It is a useful tool for investigators because it does not contain the functional domains that promote systemic cell proliferation or IGF-1 activation. It is therefore an important control agent and active test in comparative peptide biological studies conducted across the United States of America, Canada and Australia.

What is AOD 9604 and what does it do?

AOD9604 is a synthetic analog peptide composed of 16 amino acid. It is classified strictly as a research reagent, despite its historical development name. It is structurally the same as the hGH
177−191 area, but with a modified structure profile to increase chemical stability.

Structure and Classification of Peptides

AOD 9604 is a truncated fragment of a growth hormone mimic, but it has a very distinct functional profile. The solid-phase peptide syntheses the primary amino acid sequence to match the spatial arrangement of native hormone’s terminal loop. The tyrosine helps to protect the molecule against rapid enzymatic degradation during In vitro incubation.

Scientific History and Research Interest

The unique structure isolation of AOD9604 research peptide is the primary interest for researchers. The peptide provides a model that is free of residues that are responsible for systemic effects on growth. Researchers use this molecule to:

• Receptor binding dynamics on adipocytes membranes.
• Modulation of intracellular levels of cyclic Adenosine Monophosphate (cAMP).
• The transcription of specific metabolic genes profiles in laboratory models.

AOD 9604 SCIENTIFIC RESERVES

Laboratory studies involving AOD 9604 are heavily focused on cell signaling dynamics and structural biochemistry. The peptide is a functional domain that can be isolated, and it offers a unique opportunity to study how partial peptides can affect complex enzyme pathways.

Experimental Research Environments

Researchers use AOD 9604 in controlled environments to test its interaction with primary cell cultures and lipid matrixes. These studies aim to better understand the secondary messenger systems activated by the C-terminal segment binding to the cell surface. The isolated fragment, unlike full-length hormones behaves differently in varying pH and enzyme conditions. This makes it a popular subject for structural stability and degradation tests.

Methodology Considerations

Researchers must take into account several biochemical variables when designing methods for AOD 964 peptide assessment:

• Media composition: The presence serum proteins in the culture media can affect peptide binding.
• Reconstitution vehicles: Diluent choice affects the final conformation and ionic strength of the peptide.
• Temperature Controls Thermal fluctuations can cause structural unfolding of peptide chains or their aggregation during assays.

STORAGE AND HANDLING GUIDELINES

Proper storage and handling are critical to maintaining the structural integrity of lyophilized AOD 9604. Peptides are susceptible to chemical degradation via hydrolysis, oxidation, and physical aggregation if standard laboratory protocols are not strictly observed.

Temperature Considerations

• Long-Term Storage: Lyophilized vials should be kept in a commercial freezer at -20℃ or lower. For extended preservation exceeding 12 months, storage at -80℃ is recommended.
• Short-Term Transit: The freeze-dried matrix allows for ambient temperature stability during standard shipping; however, vials should be returned to sub-zero storage immediately upon arrival.
• Post-Reconstitution: Once transitioned into a liquid state, the peptide is highly vulnerable to degradation. Liquid solutions should be stored at 2℃ to 8℃ and utilized within a designated experimental window.

Environmental Safeguards

To prevent premature degradation, keep the vials protected from direct light exposure, which can induce photo-oxidation of sensitive amino acid residues. Additionally, ensure seals remain intact to avoid moisture infiltration; atmospheric humidity introduced into a cold vial can cause condensation, leading to rapid peptide hydrolysis.

FREQUENTLY ASKED QUESTIONS

What is AOD 9604?

AOD 9604 is a 16-amino acid synthetic peptide modeled after the C-terminal fragment of human growth hormone (hGH177-191) with a terminal tyrosine modification. It is developed strictly as a research reagent for laboratory analysis.

How should AOD 9604 be stored?

For long-term storage, AOD 9604 storage requires a temperature of -20℃ or lower in a moisture-free environment. Once reconstituted, the solution must be refrigerated at 2℃ to 8℃ .

What does lyophilized peptide mean?

Lyophilized AOD 9604 refers to a peptide that has undergone a freeze-drying process to remove water. This process enhances the shelf-life, preserves structural purity, and ensures stability during transport.

Is AOD 9604 intended for human use?

No. This product is classified exclusively as a research peptide. It is not approved for human consumption, medical treatments, therapeutic use, or any form of clinical administration.

What is peptide reconstitution?

Peptide reconstitution is the process of re-dissolving the lyophilized powder into a liquid solvent, such as bacteriostatic water or sterile water, to prepare it for laboratory assays and experimental testing.

What is the purity level of this peptide?

Our research peptides are manufactured to a verified analytical purity standard of ≥98%, confirmed via High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry analysis.

Can this peptide be stored at room temperature?

While the lyophilized form can tolerate room temperature during shipping transit, prolonged exposure to ambient temperatures will accelerate degradation. Immediate sub-zero storage is required upon delivery.

What research fields utilize AOD 9604?

It is primarily utilized in structural biology, biochemistry, endocrinology research, and academic studies investigating the cell signaling pathways associated with growth hormone fragments.

SCIENTIFIC REFERENCES

1. Peer-Reviewed Journals: Consult academic publications such as The Journal of Peptide Science, Metabolism, and Endocrinology for peer-reviewed studies regarding C-terminal growth hormone fragments.
2. Research Institutions: Review structural biology and molecular biochemistry repository data published by leading global research universities.
3. Scientific Databases: Cross-reference molecular properties, mass spectrometry profiles, and synthesis verification data via PubChem and the National Center for Biotechnology Information (NCBI) databases.